CleanPlex®神經遞質紊亂面板是一種預先設計和定制的基于多重PCR /擴增子的靶向測序（NGS）分析方法，旨在檢查與神經遞質紊亂相關的22個基因的種系變異或突變。該小組針對這些基因的所有外顯子區域和側翼內含子序列。僅需10 ng DNA即可兼容測序就緒的文庫，只需3個小時即可使用簡化的工作流程進行準備。預先設計的面板經過計算機優化，可提供具有高目標性能和高覆蓋均勻性的數據，以確保有效利用測序讀數。
該產品是定做的。收到您的訂單后，我們將合成面板，該套件將包含CleanPlex Multiplex PCR引物和CleanPlex Targeted Library Kit。可以分別訂購CleanPlex索引PCR引物和CleanMag®磁珠，以完成從輸入DNA到可測序的NGS文庫的工作流程。
Gene List: ABAT, ALDH5A1, ALDH7A1, ARHGEF9, DBH, DDC, GAD1, GCH1, GLDC, GLRA1, GLRB, GPHN, MAOA, PCBD1, PHGDH, PNPO, PTS, QDPR, SLC6A3, SLC6A5, SPR, TH References: Mei D, et al. The Impact of Next-Generation Sequencing on the Diagnosis and Treatment of Epilepsy in Paediatric Patients. Mol Diagn Ther. 2017 Aug;21(4):357-373. Narwade SC, et al. Transcriptome Analysis Reveals Altered Expression of Memory and Neurotransmission Associated Genes in the REM Sleep Deprived Rat Brain. Front Mol Neurosci. 2017 Mar 17;10:67.
Gene List: ABAT, ALDH5A1, ALDH7A1, ARHGEF9, DBH, DDC, GAD1, GCH1, GLDC, GLRA1, GLRB, GPHN, MAOA, PCBD1, PHGDH, PNPO, PTS, QDPR, SLC6A3, SLC6A5, SPR, TH
References: Mei D, et al. The Impact of Next-Generation Sequencing on the Diagnosis and Treatment of Epilepsy in Paediatric Patients. Mol Diagn Ther. 2017 Aug;21(4):357-373.
Narwade SC, et al. Transcriptome Analysis Reveals Altered Expression of Memory and Neurotransmission Associated Genes in the REM Sleep Deprived Rat Brain. Front Mol Neurosci. 2017 Mar 17;10:67.